Mean the same that "man up" means to a mean. Means to dress up ect. and get all sexy and make men want to fuck them.
You got a pussy up.
by Judge dredd7 March 20, 2011
1. Act mean towards someone.

2. Act scared/scured/cowardly towards someone.
Don't pussy up now, nigga, after talking all that shit.
by Mr. Terrence L. Trezvant September 04, 2006
To toughen or "man" up. Thought up by the GameGrumps, based on the logic that ball sacs are fragile whereas pussies can "take a pounding."
"Stop being such a little sensitive dangling balls and fuckin' pussy up." -Arin, Pokemon FireRed, Episode 48
by Soapy's Image November 06, 2014

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