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2.
To get high, particularly by shooting up heroin.

Used frequently in the movie, "Requiem for a Dream."
"Let's get something to eat."
"We should push off first."
by Mr. Ree January 25, 2006
 
1.
to go inject heroin
lets go push off
by dopefiend November 11, 2003
 
3.
an exclamation from Britain meaning, "go away or get lost!"
"What a mankey git, hey push off!" said Clara to the creepy man, attempting to make offensive smalltalk to her.
by viking_on_stilts May 01, 2007