The rare, and complicated, act which consists of the following illogical female bullshit: skankily going home with a guy you just met and having sex with him (without even giving him head), followed by puking all over his bed and carpet. As if that didn’t destroy the evening, you complete the act by dropping a nuclear bomb of a phone call the next day that you aren’t on birth control even though you said nothing when he was fucking you raw.

The nuclear bomb is usually followed by the man purchasing a $50 PlanB pill and awkwardly delivering it to the skank (see: Hazmat Clean-Up).
Skip: Dude, what happened with that chick that was all over you on the dance floor last night?

Bro: Everything was fine until that trick dropped a Puke & Nuke on me. I just drove a fuckin hour each way to her house for the Hazmat Clean-Up. It was a debacle.

Skip: Shit, you got owned!
by king j$ August 9, 2010
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A massive explosion of vomit, covering several rooms, coming from a wasted guy/girl after a night of heavily drinking.
Friend: Wow, it smells! What happened?

Dude: I totally made a Puke Nuke last night.

Friend: Wicked!
by Masterpuker November 3, 2010
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this doesnt have to happen on the shitter(toilet), but it does have to happen at the same time. The pukin part would be throwin up like shit fuck crazy, and the nukin part is when your on the shitter, you shit like crazy, unlike any other; you blow up the motherfuckin toilet with shit like james woods in Scray Movie 2.
I had to puke n nuke the toilet last night from all that drinking. Felt like Nagasaki and Hiroshima up in that mother.
by garcij04 January 24, 2008
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What usually happens when you end your night of drinking with an Irish car bomb, or any other drink involving Baileys and/or Guiness.
I almost made it to the cab before I got hit with the nuke puke.
by beers R great March 10, 2009
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