(adj) A breast with a big, thick nipple
Susan has the best puffies I've ever seen!
by Anonymous February 20, 2003
2 more definitions
A breast in which the areola stands out slightly from the rest of the breast.
I can see her puffies right through her shirt!
by Ray March 14, 2005
to take a drag off of someones lit cigarette.
Can I have a puffie?
by dopplewangerM June 13, 2009