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A response of derision, dismissal or unappreciation. A noise to reject opinions or ignore interjections. Negative.
Person 1 "Delia is well fit". Person 2 "Psshhh".

Girl 1 " Emmerdale is the best soap." Girl 2 "Psshhh. Eastenders all the way."

Boy 1 "Jennifer Aniston is as hot as it gets." Boy 2 "Psshhh. Angelina Jolie. Psshhh."

Unwelcome stranger "Hey baby." Unsuspecting victim "Psshhh."
Psshhh by Hoezyn December 29, 2009
Related Words
A sound generally used to convey annoyance.
Person 1: I'm bored.

Person 2: So am I, but I'm not complaining.

Person 1: Pssht.
pssht by Christian Waters October 8, 2006
This is a sound, usually used in disgust, agrivation or disbelief. It can mean a number of things, "such as screw you", "whatever", "fuck off", or "yeah right"
MARY; OMG! I just got tickets to the concert
BARBIE: OMG! when are we going?
MARY: Well I can only bring one other person, so I picked
Suzie
BABIE: PSSHHHT, I didnt even wanna go to that concert anyway.
psshhht by Donlyone November 9, 2008

pssht, I knew that... 

What you say so you won't look stupid in front of your crush, when you really did not know that.
Alisha asked what period they had next although this was the last period of the school day. She brushed it off with a, "Pssht, I knew that..." when her crush walked by.
pssht, I knew that... by ahaha<3 November 20, 2010
It can mean whatever you want as it is used in many situations.

It is most commonly used when a person is annoyed or disagrees but can be used to agree and insult and whatnot.
Guy1: I want some Kool-Aid.
Guy2: Pssht, that shit is amazing.
Guy1: Pssht yeah it is!

Guy1: What's up man wanna go hang out?
Guy2: Pssht. (walks away)
Guy1: Pssht.
Pssht by Sean W D June 10, 2009
The sound Will Smith and DJ Jazzy Jeff made when they did their signature handshake on the Fresh Prince of Bel-Air sitcom.
Wat up Will! Psshhh!
Psshhh by tim timmah 27 June 14, 2008