Warm spit and/or the shitty residue left in a man's anus after taking an extremely sticky shit.
Hey, Tyrone. Earl raped you using prison lube, you bitch nigga.
by Doctor Thunderrocket August 30, 2007
1 more definition
The spit that goes on a penis before insertion into a dry hole
Mike Tyson said he used prison lube when he had intercorse with that girl.
by Tracey September 05, 2003