Warm spit and/or the shitty residue left in a man's anus after taking an extremely sticky shit.

Hey, Tyrone. Earl raped you using prison lube, you bitch nigga.
by Doctor Thunderrocket August 30, 2007
Top Definition
The spit that goes on a penis before insertion into a dry hole
Mike Tyson said he used prison lube when he had intercorse with that girl.
by Tracey September 05, 2003

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