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1.
The spit that goes on a penis before insertion into a dry hole
Mike Tyson said he used prison lube when he had intercorse with that girl.
by Tracey September 05, 2003
 
2.
Warm spit and/or the shitty residue left in a man's anus after taking an extremely sticky shit.

Hey, Tyrone. Earl raped you using prison lube, you bitch nigga.
by Doctor Thunderrocket August 30, 2007