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1.
When someone is angry at someone or something in their frustration they yell Prick off. A less rude way of saying to fuck off.
Will you just prick off!
by Ash & Chris June 28, 2006
 
2.
A spray that keeps pricks away from you
I had to use prick off on johnny. He is such an asshole
by FuCk ThE pRiCkS July 02, 2009