Top Definition
A condition where girls with a naturally pretty face, put no effort into their body and generally end up fat and out of shape. The opposite of Butterface.
With such a pretty face that girl could be super hot if it wasn't for her pretty face syndrome.

Damn shame shes got PFS, she could be so hot.

Picked up a good looking girl last night, but when I got her naked turned out she had a serious case of pretty face syndrome :(
by HunkeyMonkey February 15, 2010

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