Top Definition
PMS on crack.
Premenstrual dysphoric disorder (PMDD) is an illness associated with the luteal phase of the menstrual cycle. It is characterized by severe irritability, anxiety and anger. It is similar to premenstrual syndrome (PMS), but differs from it in severity and in that it requires treatment, because it interferes in a woman's ability to function in her environment.

There is some question as to whether PMDD has been "marketed" by pharmaceutical companies in order to increase the demand for treatments.
by _chloBOTxxx March 07, 2006
PMS with a twist.

This is not your everyday PMS. This is a severe form of PMS that can trigger super irritability, anger, manic/depressive states and homicidal feelings. Trust me. I've been there.

PMDD kicks PMS ass any day. It is the mothership of premenstrual symptoms. PMDD would make a woman wanna rip her ovaries out, burn them and rejoice afterwards. Fucking PMDD, yo mama.
by twistedbabydoll August 05, 2007
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