British slang for "Down Syndrome", also slang for "autism" in other areas of the UK.

This slang term was developed so that people could speak about it in public without offending those afflicted with either illness.
It is popular in the "Wales" region.
i'd hate to be afflicted with plex, that guy with plex can't even come up with anything on his own
by rus_IMN November 01, 2012
Another word for "Floss". A twist on the word "flex". Means to show off fancy clothing, cars, jewelry, etc....
"I floss even though they hate me/ Pull up in Vette's/ Humvees and Jets/ Watch me Plex/" - from "I Shyne" by Killa
by Lil SB February 17, 2008
The equivalent to a pussy usually used when a parent or guardian is around and you can't say "YOU'RE SUCH A PUSSY MARK JUST JUMP OFF THE DAMN TREE!"
"Mark is a huge plex he still doesn't like girls he thinks that they have cooties."
by jack anthony January 18, 2008
to interfear with.to cause physical or mental duress or harm.
"He plexed him"."John is a plex robot"
by kungfublood July 18, 2003
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