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5.
Contrary to common misconception this infact means very good or amazing. One is often amazed at the amazingness of something when using this phrase.
Guy 1: "I just won a million pounds.."
Guy 2: "zOMG, DAT IS TEH PLAGUE!111! WANNA BE BFFL M8!!?"
Guy 1: "FU bish"
by Madame Bugatti August 25, 2008
 
1.
1) A serious and spreading sickness.

2) A serious and spreading problem.

3) That which is borne by the PlagueBearer.
1) The plague spread through New Hampshire, making many cough and die.

2) The rats were a serious plague, which Great Britain intended to handle quickly.

3) PlagueBearer sure bears plague.
by Mimir September 23, 2003
 
2.
an illness that wipes large numbers of living organisms out of existance.
"Oh dear I have seem to have caught the plague"
"Oh dreadfully sorry"
"Don't be I have growen weary of liveing"
"OH then it's all for the best"
"indeed"
"indeed"
by Nathan Hickey May 17, 2005
 
3.
A term to define a crowd of negative, hateful, vindictive, malicious, abusive, people who have no concept of kindness, consideration, or "Harm None", despite the number of "Wiccans" in the actual crowd. See lemmings, sheep, queen, clannie, spellchecker, guinness, cancer.
"You goin' out tonight?"
"Naw. The plague of people that will be there makes me want to just rent movies at Blockbuster, and stay my ass home."
by NottaFanNEMore December 06, 2004
 
4.
a variation of the word 'sick', as in awesome, cool, tight, etc.

'bubonic' may also be used in place of plague
Did you catch the concert last night? The band's drumming was hella plague!
by ClaraAnne March 11, 2009
 
6.
tr00 Black Metal band featuring Cronias on drums and Lachesis on guitar/bass.
Holy shit, PLAGUE is the tr00est band ever!
by Kannis Moloney July 22, 2005
 
7.
the ultimate robot, a bob and george like comic
damn Plague just kicked megamans ass!
by Crimsin January 08, 2004