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5.
a cyst or pustule zit, that often forms on the face of persons having eaten this delectable, cheesy food.
"I would really like to eat pizza again tonight, but I am afraid of getting another pizza tumor like the one I had last week".
by Jantha Silverhame October 14, 2007
 
1.
A large burned air bubble that sometimes forms in the crust of a pizza, rendering the slice that contains it significantly less appealing.
Customer: "I'd like a slice of cheese, please."
Sbarro employee: <Starts plating up the big bubbly piece>
Customer: "Not that one with the pizza tumor!"
by Rusty Camaro April 10, 2006
 
2.
A large, slightly burnt bubble on a slice of pizza, making it more or less appealing to the pizza eater
"Oh man gimme that slice with the huge pizza tumor"

"NO! Don't give me the one with the Pizza Tumor"
by Uabua October 14, 2007
 
3.
1. A big bubble in the dough, usually found on the crust of a pizza. Often times, this bubble comes out burnt and ruins the appearance and flavor of your pizza.
2. Also a slang term used for an "underground" pimple that can become quite large in diameter and cause redness, similar in appearance to an actual pizza tumor.
1. "Man, this was the best pizza ever! I just wish my slice didn't have that pizza tumor on the crust."
2. John was known all over campus for his terrible acne and disgusting pizza tumors.
by -Wig. October 15, 2007
 
4.
A HUGE ZIT right in the middle of a very red and purple swollen acne face of white heads.
John: Holy G's! Look at the size of that Pizza Tumor on Rubin's face!
Brandon: Ohhh baby! When that bad boy blows its gonna fill buckets.
John: Be Afraid...Be Very Afraid!!!
by CRRS October 14, 2007