Female genitalia that is covered in large area with either acne, herpes, scavies, psorisus or other know skin-affected ailmets.
"I have to fuck my wife with the lights out because Susan is covered in pimples. Why, she even suffers from pizza pussy, it's so bad!!"
Sammie: "OMG Sarah! You're bleeding through your jeans! Do you need a tampon?"
Sarah: "Oh, no, that's just the aftermath from popping the zits on my pizza pussy."
Sammie: "...that's fucking sick."
"If you look carefully, that prostitute on the corner clearly suffers from pizza pussy, probably brought on by syphalis. Look, it spreads down her thighs!"