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1.
An exclamation of frustration and/or anger at a certain situation.
John: Pissmittens I think I just ran over Steve's dog!!
by erotikhamster June 02, 2010
 
2.
Interjection. Expression of total feelings of futility, and resignation, at own idiocy.
<upon realising your only pair of boxer shorts has been caught in the aftershave fire set by your drunken housemate> fuckitty-wankitty-PISS-MITTENS!
by Trickenso September 28, 2006