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2.
A term used to express an unwillingness to engage in further conversation.
Jon: Hey Gary, are you going to get Mark that CD player?

Gary: Tell him to piss up a rope!
by The Boy Who Never Speaks November 03, 2011
 
1.
sl.
1) a futile act
2) a not-so-subtle way of asking someone to go away and not come back for a while.
"go piss up a rope, loser."
by charlie root June 09, 2003