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2.
To be filled with bitter and angry thoughts because of someone/thing.
That Jade, she fills me with Piss and Vinegar. With her stupid... brother.
by ztara April 03, 2011
 
1.
a phrase used to express an attitude of somebody that is full of energy, vigor, perhaps rowdiness or excitedness.
Dottering Old Man: Well hello there young fella! How might you be feeling today?

Timmy: I'm full of piss and vinegar, you crotchety ol' coot! Now, outta my way, I'm going to play with my friends!

Dottering Old Man: Good to hear! Say, I'll give you a lollipop if you squeeze my testicles two or three times!
by Palcon_Funch July 14, 2011
 
3.
What someone is full of when they are causing trouble to someone or being sarcastic.
John was full of piss and vinegar when he interupted the quiet meeting with his fart jokes.
by cherl February 26, 2006