Top Definition
When a doctor tests certain medications on a patient, but actually worsens the problem through trial and error.
Micky: my doc put me on antidepressants... but it actually made me suicidal... so he put me on another kind and now don't give shit about anything... so now he thinks I need a different kind... I feel like a lab rat!

Mallory: Sounds like pill roulette to me.
by PDXJohnny99 April 10, 2013

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When you put all of your dad's pills in a bag and take turns in blindly taking them out
John: let's play pill roulette!
Jay: done
John: I got heart meds
Jay: I got 2 endone's
Mum: I got panadol, booooo
Jay: winner
by VonnyEvil April 03, 2016

The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

Lotsa space for your liquids.

Buy the mug

The Urban Dictionary Mug

Your favorite word on a white mug.

Create a mug

The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

Buy the mug

The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

Buy the t-shirt

The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt