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1.
something to brighten your day or give you an energy boost, especially useful when you can't spare time for a lunch break during a long day of work.

also, chemical mood enhancers such as alcoholic beverages.
Let's go for coffee, I could sure use a pick-me-up.
by kiki86 March 29, 2007
96 6
 
2.
something to keep you going whether if be an energy drink or a bump of some blow
i need a pick me up cuz i havnt done any shit for about an hour
by e-haw420 June 24, 2008
78 6
 
3.
A little some thing someone says or does to make a sucky day turn in to a good day.
friend 1 "There's no drama in my life, there's no drama in my life. repeat until haters go away"

Friend 2 " wow you just made me smile ! that was just the pick me up I needed "
by realgothy September 12, 2011
15 16