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1.
What you say when someone's supposed to choose between two horrible options.
You could either chop off your toe or you can stab yourself with that piece of broken glass. Pick your poison.
by xSOMx May 23, 2010
 
2.
A gay saying used by fagmo's.
"We got gin, vodka, and rum. Pick your poison."
by Franky March 29, 2004