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1. pernicious
adj. causing great harm, or death, or something else real bad.
DAMN that was a pernicious fart.
by Emetic Aug 28, 2003 add a video
2. pernicious
Describes something that really messes you up. Most of the time you can't tell at the beginning but before you know it, it really fucks you up.
Person 1: It ain't worth it bro, you know Prozac is pernicious. Don't take it.

Person 2: Too late, I can't get off of it now.

Person 1: Damn, I hope you don't get erectile dysfunction like that other kid.

Person 2: Too late for that too...
3. pernicious
adj: an all purpose word for something cool, hip, or awesome; or evil, twisted, and sick. Also functions well as a nickname.
Example of cool: Dude, Lord of the Rings: ROTK was SO pernicious!

Example of evil: Our algebra homework last night was PERNICIOUS! I didn't get any sleep!
by Niph Apr 24, 2004 add a video
4. pernicious
The best type of deed!
Freyalise set up us the bomb; Yawgmoth will pay for his treachery; Freyalise performed her pernicious deed.
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