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5.
To be in or produce a permanent state of contextual existance in which parties involved are completely and utterly fucked, with no conceivable reprieve and from which there is no escape. See also FUBAR
Guy 1: So how'd your GF know you were cheating? You get ratted out?
Guy 2: No she's got a videotape.
Guy 1: Dude, you're permafucked.

A gangmember rapes a hooker in an alley. Little does he know that the hooker has AIDS. Now he's facing charges of sexual assault, the pimp wants revenge and on top of it all he's gonna die from AIDS in a couple of years. You don't get more permafucked than that.
by Lord CrutchCricket November 01, 2007
 
1.
An adjective that means you do so many drugs that your brain is permanently fried. You forget how to do easy things, like remember to go to class or put your car in park.
Dude A: Hey dude did you see Cody at lunch today?

Dude B: Yeah dude he's been there for three hours and just got detention for skipping class. He's totally permafucked.
by poolmaster41 April 21, 2009
 
2.
The name of the novel that was featured on the show Weeds. It was written by Andy's crazy ex-girlfriend from Alaska. "Permafuck: A Journal of Spirit Rape"
We are in serious trouble.

I know. We're permafucked.
by Mark Fredericksen January 05, 2008
 
3.
Taking a diploma, certificate, license, etc; glueing this to a piece of cheap wood, then covering with a permanent clear coat product. circa 1975
After I graduated from college, my father (permafucked) my diploma.
by Dr Rob April 19, 2009
 
4.
To be in or produce a permanent state of contextual existance in which parties involved are completely and utterly fucked, with no conceivable reprieve and from which there is no escape. See also FUBAR
Guy 1: So how'd your GF know you were cheating? You get ratted out?
Guy 2: No she's got a videotape.
Guy 1: Dude, you're permafucked.

A gangmember rapes a hooker in an alley. Little does he know that the hooker has AIDS. Now he's facing charges of sexual assault, the pimp wants revenge and on top of it all he's gonna die from AIDS in a couple of years. You don't get more permafucked than that.
by Lord CrutchCricket November 01, 2007