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1) A female with leathery skin, from too much time in tanning booths and/or plastic surgery (see "Lipo-Lizard")

2) A female with an obnoxious disposition, ie annoying, arrogant, talkative, etc.
"That chick Britney's skin looks like beef jerky. She's a real peppersteak"

"She's been mouthing off all night long...man, what a peppersteak"
by Mr B Shamrocks November 26, 2006