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1.
Is originally a show from Fuse but is usually used as a way to explain an event thats so awesome it makes you want to take your pants off and dance to the occasion. Thus, "pants off dance off".
Example 1. PANTS OFF DANCE OFF!!!

Example 2. Michael's concert is going to be a real pants off dance off.
by Fun on a bun July 24, 2006
 
2.
Has to be the coolest show on Fuse. Bunch of people who are obviously not easily embarrassed, dancing to music videos. Oh yeah, and in their underwear. haha. Then we get to vote for our favorite!
"Why did you want to be on 'Pants off dance off'?"
"Well, i can get jiggy with it, and I have like really cool moves."

^haha. The people are hysterical
by Yeah I'm Cool June 28, 2006
 
3.
only the most kick-ass show ever. on fuse.

what's better than people of all ages, shapes, sizes stripping to music videos?
"Have you seen Pants Off Dance Off on Fuse yet?"
"Heck yes! I so wanna be on it!"
by Miss Dorkette May 03, 2006