The region is formed by the departamentos (provinces) of Antioquia, Caldas, Risaralda and Quindío. Some regions of Valle del Cauca (north) and Tolima (west) belong to the cultural identity of paisas. The main cities are Medellín, Pereira, Manizales and Armenia.
Although the expression "Paisa" is of popular use as apocope of "Paisano" (one from the same country; countryman).
The paisas have been considered a genetically isolated population according with researches. They are predominantly European ancestry because it is said that the male Spaniards who settled the region during the 16th and 17th centuries came with their women.
Paisas are well known in Colombia for their kindness and welcoming aptitude to persons from other regions and visitors.
An inhabitant of a rural or remote area who is usually characterized by an utter lack of sophistication and cultivation.
Usually mexicans from rural areas (like northern mexico) take this term as derogatory. To them it is like calling them "indigenous", "ignorant" and/or "flamboyant".
See also naco.