To behave in a manner opposite of normal life resulting in any form of altered mental state, usually as a result of heavy consumption of alcohol. Behavior is akin to a semi truck with no fucking brakes. Inspired by the song of the same name, written and performed by the glorious, genius Lil Jon himself.
Much like the phrase get your mind out of the gutter, which is said when someone is thinking dirty, but instead of dirty thoughts, your telling them to stop thinking homo thoughts; often used when someone reacts in a gay way.
Nick: Your mother.
Chirs: Fuck you.
Nick: What time? lol.
Chris: Dude.. get your mind out of the gay gutter.