To behave in a manner opposite of normal life resulting in any form of altered mental state, usually as a result of heavy consumption of alcohol. Behavior is akin to a semi truck with no fucking brakes. Inspired by the song of the same name, written and performed by the glorious, genius Lil Jon himself.
A condition where you are not thinking properly. Not in your normal state, not working with your normal faculties. Out of your gourd, feeling crazy enough to do something you would never normally do. Generally considered to be related to the odd behavior of heat stroke victims or victims of exhaustion, conditions that people who would pick cotton for a living in very hot or very stressful conditions might end up suffering.
"What did you do THAT for? Are you out of your cotton-picking mind?"
"He's babbling like an idiot, like he's out of his cotton-picking mind."