Top definition
to say someone is crazy, a fool
When May and Mary went screaming and running crazily down the street, dad muttered, "You two are out of your cotton-picking minds."
by Aura173 June 27, 2006
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2
A condition where you are not thinking properly. Not in your normal state, not working with your normal faculties. Out of your gourd, feeling crazy enough to do something you would never normally do. Generally considered to be related to the odd behavior of heat stroke victims or victims of exhaustion, conditions that people who would pick cotton for a living in very hot or very stressful conditions might end up suffering.
"What did you do THAT for? Are you out of your cotton-picking mind?"

"He's babbling like an idiot, like he's out of his cotton-picking mind."
by Nightowl223 May 20, 2016
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