Top Definition
This refers to the phenomenon of the behavior of young single women on vacation. Due to the fact that they are away from familiar people they become generally more impulsive and specifically much more sexually permissive than they otherwise would be. This phenomenon can often be observed on cruise ships as well as any vacation spots that are popular for young single people. As the end of a young woman's vacation or trip nears, the more acute the syndrome becomes.
Guy 1: These girls are crazy man! They're taking their tops off in the club and one of them just gave me a blow job in the bathroom. I've never picked up women so easily before. They must be nuts!!!

Guy 2: No man, they just have out of town syndrome.
by Billy1980 July 13, 2010
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