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5.
Sometimes referring to a one punch knock out and also referring to marijuana that after only one toke your all done somking because your so blown out
Shay hit Chris with that one hitter quitter after he snitched /

Shay grew the best weed I ever smoked, definitely some one hitter quitter
by Shay Muny April 12, 2008
 
1.
A way to describe some bomb ass chronic
Lets go blaze sum of dat one hitter quitter shit.
by head November 29, 2003
 
2.
getting knocked the fuck out wit one punch!
dont fuk wit me i got that one hitter quitter
by Raul November 13, 2003
 
3.
1.) The action of knocking someone unconscious with one blow of the fist, usually in the face, where the person does not regain consciousness for an extended period of time.

2.) Referring to marijuana. A person, relatively new to marijuana, who inhales one hit usally under the pressure of peers, and pretends to act high because the lack the knowledge of what high feels like.
1.) Did you see the one hitter quitter that disfigured Brian's model face?

2.) My friend used to be a one hitter quitter, quite often making the claim that he got high because he weighed less.
by Adam Shatter October 04, 2005
 
4.
An extremely effective punch directly to the nose of a punk bitch that essentially ends a fight after one punch. To perform correctly, every ounce of strength must be summoned from inside of you culminating in a lethal blow. If the asshole who receives the blow ever comes back to bother you again then you didn't do it properly.
After that gel-haired asshole with the muscle shirt bumped in to me in the club for the second time I gave him the one-hitter quitter.
by C. Griffin October 23, 2007
 
6.
In addition to being a term for good marijuana, or getting knocked with a single punch, its also a phrase for anything that has a sudden impact. For instance, a disastrous tornado or hurricane would be described as a one hitter quitter. Or an athlete or athletic team particularly in football. Such as Barry Sanders or Reggie Bush who can go the distance for a touchdown at any given moment is known as a One Hitter Quitter. A team with a high powered offense attack,like the Oregon Ducks would be known as a One Hitter Quitter
" The game is close right now, but USC better stayed on their game, Oregon got that one hitter quitter"

"Man I think we need to evacuate, I hear that hurricane thats coming got that One Hitter Quitter"
by dingslinger August 15, 2011
 
7.
a person who fakes like a stoner but takes one hit (of a joint) and then says how high they are and won't smoke any more
"oh jon's just a one hitter quitter- don't smoke with him"
by lauren August 30, 2003