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6.
The phrase that people say that suck at everything but is the best in their little village where they live when they lose in a team-based. Normally followed by a really bad yo momma joke.
John: God dude, you really suck at everything.
Gaylord: what, you wanna go one on one, because I'm in your mom's bed.
John: (pause) Wow... really?
by JoshRoxxx July 29, 2008
 
1.
1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"
by dieselgirl August 07, 2003
 
2.
BASKETBALL, where you (and only you) play against one other person
I played against Santiago in a one on one basketball game
by Home slice August 14, 2005
 
3.
san francisco bay area slang for a combination of cocaine and heroin, aka a "speedball". a hit of tar heroin and powder cocaine sold together on the street for $10 to $20.
if youre in a san francisco neighborhood such as the mission, and you hear a guy calling out "one on oners, one on oners", hes not challenging you to a game of basketball.
by beau "oma" taylor March 14, 2010
 
4.
An informal code of street fighting, not allowing bystanders to interfere in the fight.
Hey bitch-ass, let's square it up one-on-one in the midldle of the street!
by PGrace August 04, 2003
 
5.
when your boss invites you to a business lunch.
by seliko June 17, 2003
 
7.
1. When you go from dating someone to being in an exclusive relationship.
2. Becoming someone's boyfriend or girlfriend.
Friend 1: Dude, when are you guys gonna go one on one?
Friend 2: I'm not ready for a relationship yet.

Friend 1: I thought you were going one on one with her.
Friend 2: Naw, man. I don't want to give up the other pussy.
by Juppy George January 16, 2009