2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"
Gaylord: what, you wanna go one on one, because I'm in your mom's bed.
John: (pause) Wow... really?
2. Becoming someone's boyfriend or girlfriend.
Friend 2: I'm not ready for a relationship yet.
Friend 1: I thought you were going one on one with her.
Friend 2: Naw, man. I don't want to give up the other pussy.