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2.
1. ambitious and aspiring, especially in a ruthless, exploitative way

2. offering and seeking sexual gratification or conquest
Unfortunately, when one tyrant falls, another is likely to be on the make.
by The Return of Light Joker June 07, 2011
 
1.
on the prowl (looking for a sexual partner)
guy1: how does it feel to be on the make again?
guy2: what decade did you learn that from?
by guided fox May 27, 2006
 
3.
working towards making money, i.e. a plan with a cash reward.
"Don't worry about cash...I'm on the make."
by Mackey January 04, 2005