Guy2: o lawd.
Grandpa: Back in my day, we used pine cones and tampons!
Impressionable Children: o lawd, here we go again.
KFC Clerk: May I take your ord-
Black Women: O LAWD GET ME A BUCKET O' CHICKEN.
Usually said in rejection or disapproval to an idea or an event that has occurred.
<me> O LAWD! WHAT AM I GONA DO NOW?
<fag> So, how's the weather.
<me> o lawd, it's a hurricane! I think im loosing interweb!
<fag has now been blocked>