When you are royally fucked.
3 little girls are on a tube ride in their local lake. They hit a monster wave, and all 3 of them fly off of the rub screaming oh noes!
Something you say when the FBI or the police are at your door, and they are after your LUNIX.
Casual use can be caused by a combination of displeasement and fear for Microsoft lawsuits against open source operating systems, such as Redhate Lunix. It may include other, less important things.
JeffK: "Oh noes, teh police! HIDE TEH LUNIX!!!11"
"Oh noes, I forgot to take your bro out of the oven!"
Used when something that happens that is the worstest thing that could ever happen, seemingly.
When Darth Vader tells Luke Skywalker he is his Father.
Darth: "Luke, I am your father!"
Luke: "Oh Noes!"
The most awsome expression of dismay ever.
1. OH NOES ITS OPERCAB00SE!!
2. OH NOES TEH HAXX0RS STOLED MY MEGAHURTZ!! what shall I do?!?!/1
What to say when the giant, rhinoceros-like alien comes to eat you in your poorly-constructed marine base.
"OH NOES!!!11" exclaimed teh Cyphage, mere seconds before the enzymes met his skin.
When something bad has happened or is about to happen, you shout OH NOOOOESSS as a replacement to the dull, tired "oh no". Extra o's and e's can be added for extra emphasis.
OH NOOOEEESSS!!! My lunch is over!
Variant of "Oh no!", used sarcastically to indicate that what is being referred to is NOT, in fact, something to be alarmed about.
"My World of Warcraft server's economy is ruined! I can now only sell Arcane Crystals for 7 gold coins apiece, whereas before I could sell them for 8."
1) A response to a negative situation which is insignificant, or at worst, a temporay inconvenience.
2) A response to a negative situation occurs on a regular basis, to the point where it is expected.
Guy A: "Aw, man, the Marlins lost"
Guy B: "Oh noes!"
Guy A: "Windows crashed again."
Guy B: "Oh noes!"