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1.
Very fucked up from substance abuse, can also be alcohol.
"That cunt is 'off his tits' in class every day."
"You were so 'off your tits' last night that you gave the taxi driver a $100 bill and said keep the change. Luckily I grabbed the money, but I yo' aint getting it back. Serve's yo' right for being so 'off tits'."
by Diego September 11, 2003