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1.
To be absolutely fucked from taking drugs or drinking too much liqour.
Often said Off me guts.
"I waz off guts at that party last night."
"I hope this bikkie gets me off me guts."
by Diego September 11, 2003
 
2.
Some one that has consumed too much MDMA and is in a trance like state
I ate 8 pills the other night I was so off guts
by OGP August 27, 2003