Top Definition
Osis is an acronym that stands for "On Some iLL Shit" O.S.I.S created by Zayah G
"Dam jboy looking Osis"
"That guy over there look like he Osis"
"He Osis Af"
by zayahg January 26, 2017

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A world that means "o really" in Spanish used commonly by Salvadorians in a sarcastic way
guy 1- just banged da grl i told i told u about
guy 2- y u lying
guy 1-na for real dude
guy2- oooooo siiiiiii jajajajaja
by ElonlyS0n1x August 27, 2007

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osi
a cheap-ass, lolicon lover, bisexual, asian, sexy beasts-hater ,bastard.
You're such an osi, you should go die.
by =P December 26, 2004

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Osi
True elite sexiness wrapped up in a homosexual vibe, or execing the cfg.
I want to be like Osi. - I want to be elite, sexy and a cfging homosexual
by Osi February 13, 2003

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