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Usually used when crazy shit goes down and there is no other phrase in the English language left that can be used to properly express ones feelings.
John: Theres a pack of wild gnomes outside. They're roaming around raping and killing everyone and everything. The leader of the pack, an overweight bear with a top hat, is demanding the destruction of all things as he roles in the blood of the fallen.

Randy: Nyoh my god.
by salty mcballstien October 29, 2010