One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
by mush01 July 31, 2008
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An adapted quote from the movie Aliens, to 'nuke it from orbit' means 'to come in a woman's face'
"That bitch's face annoys me"

"I'll be chucking one up her later, if it makes you feel any better, I'll nuke it from orbit"
by cancermerchant August 13, 2008
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... it's the only way to be sure.
Typically used as "nuke IT from orbit," but seen in other forms.
Tom: OMG, the HForums are full of faggotry.
Dick: Yeah, we should nuke them from orbit.

Note: pronunciation is as close to IPA as I can manage without weird fonts.
by ZPrime October 20, 2003
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When, during sex, a man stands on the bed and the other party gets on their knees as the man cums all over them.
Phil: yeah man, me and Sarah were doing the deed and she asked to be nuked from orbit, so I figured why not?
Jeff: kinda weird but you do you
by I_gotta_shit January 12, 2023
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When the moderators of Growtopia decides to ban a world and nuke it from orbit.
Bro, how did you get cursed for 8 hours?!
I was playing casino and the world got nuked from orbit by the mods
Shit that sucks man
by proedu October 15, 2020
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