One step up from kill it with fire
, usually followed by the phrase "it's the only way to be sure."
A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."
Generally used in response to a clusterfuck
, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
An adapted quote from the movie Aliens, to 'nuke it from orbit' means 'to come in a woman's face'
"That bitch's face annoys me"
"I'll be chucking one up her later, if it makes you feel any better, I'll nuke it from orbit"