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1.
One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
by mush01 July 30, 2008
 
2.
An adapted quote from the movie Aliens, to 'nuke it from orbit' means 'to come in a woman's face'
"That bitch's face annoys me"

"I'll be chucking one up her later, if it makes you feel any better, I'll nuke it from orbit"
by cancermerchant August 13, 2008