A particular person or person's idea that is out of whack or off kilter. In reference to the popular t.v. series LOST in episode 10 (season 1). Hurley is shocked and confused when he discovers that Ethan Rom (guest-star William Mapother) does not appear on the flight manifest, and thus was already on the island before the crash.
Larry came over the other night and out of nowhere just started rambling on and on about his prostrate. He was so far off the manifest it wasn't even funny. - or - Dude that ugly chic has been eyeballing you all night long. I don't think she's on the manifest. - or - Then the guy just ate a scorpion. He is definitly not on the manifest.