A vulgar term referring to the direct male descendant of a female dog. It is used in a condescending tone to mean "son of a bitch." It is the ultimate comeback and will leave certain members in tears.
That guy wouldn't give me any of his weed! What a nopalero!
by UpdogULTIMATE May 02, 2008
The term used 4rm other ppl in central or south america referring to those taco selling pancho wearing mexicans.
Hey look at those nopaleros trying to cross the border.
by Pancho Villa Jr. July 02, 2007