Indicating that an action has no chance in happening whatsoever.
Dude: When i grow up, i'm gonna be a successful millionaire.
Other Dude: no shot
never getting any pussy(BOX)! to be celebate for a long time! to never have nothing sexual in your future but intensive self-satisfying masterbation!
Josh, Tim, or Matt(Yoder)have "no shot" when they meet a skank or any female for that matter!