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1.
you don't know it until you do/try it
Example 1
Kid - I bet there's no more chips in the closet.
Other Kid - Never know..
(He want's the kid to get more)

Example 2
Girl - I bet he's not going to like me..
Other Girl - You never know! :D
(The other girl is giving her confidence)
by radicaldude February 18, 2010
 
2.
A concept introduced in Robert Cormier's novel, I Am the Cheese, which refers to day-to-day uncertainty in life that can result in everything from a vague feeling of discontent to crippling fear
Oh man. I can really relate to the concept of "the Never Knows", and, in my opinion, anyone who cannot is either very lucky or an extreme sociopath.
by Adam "the Cheese" Farmer May 14, 2010