1. An episode of television programming involving Muppets.

2. A moment when a person becomes so animated that they take on a Muppet-like quality, usually in a deeply amusing way.
1. I love the muppisode where Bunson turns Beaker into a ball of flame.

2. She got so excited she knocked over her wine. Total muppisode.
by Rattiemama February 03, 2010

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