look up any word, like trill:
 
2.
a substitute for mother fucker.

pretty much the pussy way of talking smack.
Bob: ur gay

Fred: what did you say mother fluffer?

Bob: woah, ur too hard core for me.
by that evil giraffe November 14, 2011
 
1.
Baby friendly substitute for motherfucker.
Listen Jimmy, you motherfluffer, im not fluffin' around. Give me back my stuffed giraffe.
by tpain_cool April 19, 2011
 
3.
A relative of the word 'motherfucker' which can be used around a broader-aged audience or parental figures as to not sound like a drunken sailor.
Becky: Oh my god Jessica is such a motherfluffer
Jessica: Motherfluffer?
Becky: Yeah like my mom is right there and swearing is SOOOO two years agoooo but yeah she is soooo a motherfluffer her butt is so BIG.
by pkh456 June 13, 2014