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2.
A phrase used when something amazing, miraculous, something thought to be impossible, etc. had happened.
"Dude, try this: Make a fist with your left hand and squeeze your left thumb. Then put your right finger down your throat. NO GAG REFLEX!"

"Mother of God..."
by LucyExpress January 26, 2012
 
1.
If something unbelieveable happens or is so unexpected and you cant believe your eyes, you can then say 'Mother of GOD!'
MOTHER OF GOD!... (said a man after seeing a 24 foot pussy with legs walking towards him)
by Nick November 09, 2004
 
3.
The one and only mother of the Lord Jesus Christ, the virgin Mary. Also used to describe an undescribable event.
sweet mother of god.
by kevinator March 16, 2003
 
4.
The virgin mary, who has a habit of appearing on such objects such as tortillas and fence posts and other inanimate objects in mexico.
"holy fuck I just saw the mother of god in my fucking bean dip"
by :tbear: March 16, 2003
 
5.
The Virgin Mary

What members of Catholicism honor. Reminiscent of the ancient Roman pagan practice of honoring the mother of the Roman god Jupiter.
Mary, mother of God
by Protestant March 16, 2003