Top Definition
Mothereffer is far less-profane an alternative to motherfucker and more socially acceptable in mixed company.
That mothereffer Frank is the captain of the hockey team and the football team and gets all the fine looking girls!
by brandon667 January 14, 2010
1 more definition
What wholesome people say to avoid swearing.
Grandmother: Oh, mother effer, I just burned my hands on this apple pie!

Granddaughter: Mother who?

Grandmother: Ahhh... Mrs. Effer... yes, she lives down the street. (Runs away.)
by Joel67 April 27, 2007

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