1) short for 'most definately'
2) Hell yea; fo'sho'
3) the pun is on the rapper Mos Def, however his name is completely irrelevant to this insert
*an asian girl walks by with a big ass*
1)Would you hit that?
2)Most Def!!!
by bringas June 30, 2005
most definitely
"Should we go to 7-11?"
"Most Def"
by ryan August 19, 2002
Most definitely; for sure.
1. "He's a creeper, mostdef."

2. "Are you coming to the party?" "Mostdef!"
by edennnn June 26, 2010
(coming from "most definently")...meaning you strongly agree with someone else offer
Yo id rip that girl wide open...

Oh most def...most def
by bt June 20, 2005
Most definitely

It plays off the term, "High Def."
Due 1: "Dude, we should get more beer."

Dude 2: "Most Def."
by Beavis McButthead June 11, 2010

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